ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways (Q24321528)

GOA release 2020-03-11

MDM2 proto-oncogene

1 reference

GOA release 2020-03-11

tumor protein p53

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mdm2 expression is induced by wild type p53 activity

GOA release 2020-03-11

regulation of cell cycle

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author name string

Y Zhang

series ordinal

1

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Y Xiong

series ordinal

2

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W G Yarbrough

series ordinal

3

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language of work or name

Englisch

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publication date

20 March 1998

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published in

Cell

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volume

92

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issue

6

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page(s)

725-34

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cites work

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Mapping of the p53 and mdm-2 Interaction Domains

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Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

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Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

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Mdm2 promotes the rapid degradation of p53

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Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

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Regulation of p53 stability by Mdm2

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

9529249

1 reference

Consolidated OpenCitations Corpus – April 2017