The common biology of cancer and ageing (Q36911187)

17 August 2017

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title

The common biology of cancer and ageing (English)

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17 August 2017

Manuel Serrano

2

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Maria A Blasco

object named as

Maria A Blasco

series ordinal

3

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author name string

Toren Finkel

series ordinal

1

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17 August 2017

language of work or name

Englisch

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publication date

1 August 2007

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17 August 2017

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17 August 2017

volume

448

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17 August 2017

issue

7155

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17 August 2017

page(s)

767-774

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The serial cultivation of human diploid cell strains

17 August 2017

cites work

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Oncogene-induced cell senescence--halting on the road to cancer

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The power and the promise of oncogene-induced senescence markers.

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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Restoration of p53 function leads to tumour regression in vivo

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7 January 2021

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Cellular senescence in aging primates.

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Ink4a/Arf expression is a biomarker of aging

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The regulation of INK4/ARF in cancer and aging

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Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

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A common variant of the p16(INK4a) genetic region is associated with physical function in older people

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7 January 2021

A common allele on chromosome 9 associated with coronary heart disease

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7 January 2021

A common variant on chromosome 9p21 affects the risk of myocardial infarction

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7 January 2021

Stem cells and cancer; the polycomb connection

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7 January 2021

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

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7 January 2021

p16INK4a induces an age-dependent decline in islet regenerative potential

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7 January 2021

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

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7 January 2021

An Age-Induced Switch to a Hyper-Recombinational State

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7 January 2021

Biological mechanisms underlying the aging process.

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7 January 2021

Increased cell-to-cell variation in gene expression in ageing mouse heart

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7 January 2021

p53 mutant mice that display early ageing-associated phenotypes

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Modulation of mammalian life span by the short isoform of p53.

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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

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7 January 2021

Delayed ageing through damage protection by the Arf/p53 pathway

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7 January 2021

Mutations that increase the life span of C. elegans inhibit tumor growth.

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7 January 2021

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

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https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

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7 January 2021

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

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7 January 2021

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

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7 January 2021

Premature aging in mice deficient in DNA repair and transcription

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7 January 2021

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

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7 January 2021

DNA repair, genome stability, and aging

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The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

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7 January 2021

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

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7 January 2021

Genomic instability in laminopathy-based premature aging

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7 January 2021

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

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7 January 2021

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

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7 January 2021

Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation

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7 January 2021

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

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7 January 2021

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena

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7 January 2021

DNA sequences of telomeres maintained in yeast

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7 January 2021

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

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7 January 2021

An alternative pathway for yeast telomere maintenance rescues est1- senescence

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Telomere maintenance by recombination in human cells.

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Telomeres shorten during ageing of human fibroblasts

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Telomere length predicts replicative capacity of human fibroblasts

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7 January 2021

Association between telomere length in blood and mortality in people aged 60 years or older

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7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

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7 January 2021

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

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7 January 2021

Essential role of mouse telomerase in highly proliferative organs

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7 January 2021

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

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https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Effects of telomerase and telomere length on epidermal stem cell behavior

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7 January 2021

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia

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7 January 2021

Telomerase mutations in families with idiopathic pulmonary fibrosis

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7 January 2021

Adult-onset pulmonary fibrosis caused by mutations in telomerase

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7 January 2021

Dyskeratosis congenita -- a disease of dysfunctional telomere maintenance

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7 January 2021

Increased p53 activity does not accelerate telomere-driven ageing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Constitutive telomerase expression promotes mammary carcinomas in aging mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Conditional telomerase induction causes proliferation of hair follicle stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Telomerase activity in human ovarian carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Molecular dissection of autophagy: two ubiquitin-like systems

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Induction of autophagy and inhibition of tumorigenesis by beclin 1

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https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

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https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

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https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Autophagy and cancer therapy

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https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

The role of autophagy during the early neonatal starvation period

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https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Autophagy genes are essential for dauer development and life-span extension in C. elegans

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

p53 regulates mitochondrial respiration

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

mTOR and cancer: insights into a complex relationship

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https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

TOR signaling in growth and metabolism

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https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Genetics: influence of TOR kinase on lifespan in C. elegans

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7 January 2021

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

The search for DAF-16/FOXO transcriptional targets: approaches and discoveries.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Rates of behavior and aging specified by mitochondrial function during development

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05985

7 January 2021

Identifiers

DOI

10.1038/NATURE05985

1 reference

17 August 2017

1 reference