Notch is a direct negative regulator of the DNA-damage response (Q38884385)

7 September 2017

title

Notch is a direct negative regulator of the DNA-damage response (English)

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Fabrizio d'Adda di Fagagna

7 September 2017

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11

Fabrizio d'Adda di Fagagna

1 reference

7 September 2017

Mattia Forcato

5

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Libero Santarpia

Libero Santarpia

3

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Vincenzo Costanzo

Vincenzo Costanzo

8

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Giannino Del Sal

Giannino Del Sal

10

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Silvio Bicciato

Silvio Bicciato

9

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author name string

Jelena Vermezovic

1

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7 September 2017

Marek Adamowicz

2

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7 September 2017

Alessandra Rustighi

4

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7 September 2017

Caterina Lucano

6

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7 September 2017

Lucia Massimiliano

7

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7 September 2017

publication date

20 April 2015

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Nature Structural & Molecular Biology

7 September 2017

published in

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7 September 2017

volume

22

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7 September 2017

issue

5

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7 September 2017

page(s)

417-424

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Living on a break: cellular senescence as a DNA-damage response

7 September 2017

cites work

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The DNA-damage response in human biology and disease

21 January 2018

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Germ cell apoptosis and DNA damage responses

21 January 2018

1 reference

Death and more: DNA damage response pathways in the nematode C. elegans.

21 January 2018

1 reference

From fly wings to targeted cancer therapies: a centennial for notch signaling

21 January 2018

1 reference

Notch signaling: simplicity in design, versatility in function

21 January 2018

1 reference

Non-canonical Notch signaling: emerging role and mechanism

21 January 2018

1 reference

Notch and cancer: a double-edged sword

21 January 2018

1 reference

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

21 January 2018

1 reference

Differential regulation of DNA damage response activation between somatic and germline cells in Caenorhabditis elegans.

21 January 2018

1 reference

The establishment of Caenorhabditis elegans germline pattern is controlled by overlapping proximal and distal somatic gonad signals

21 January 2018

1 reference

Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans

21 January 2018

1 reference

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

21 January 2018

1 reference

Calcium depletion dissociates and activates heterodimeric notch receptors

21 January 2018

1 reference

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

21 January 2018

1 reference

A hierarchical cascade activated by non-canonical Notch signaling and the mTOR-Rictor complex regulates neglect-induced death in mammalian cells

21 January 2018

1 reference

The Notch signaling pathway: transcriptional regulation at Notch target genes

21 January 2018

1 reference

Alterations of the Notch pathway in lung cancer.

21 January 2018

1 reference

CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors

21 January 2018

1 reference

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

ATM associates with and phosphorylates p53: mapping the region of interaction

21 January 2018

1 reference

The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.

21 January 2018

1 reference

Studying the DNA damage response using in vitro model systems

21 January 2018

1 reference

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.

21 January 2018

1 reference

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

21 January 2018

1 reference

Aberrant activation of notch signaling in human breast cancer

21 January 2018

1 reference

Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer.

21 January 2018

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Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast.

21 January 2018

1 reference

Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis

21 January 2018

1 reference

Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue

21 January 2018

1 reference

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

21 January 2018

1 reference

Controls of germline stem cells, entry into meiosis, and the sperm/oocyte decision in Caenorhabditis elegans

21 January 2018

1 reference

Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1.

21 January 2018

1 reference

Mitochondrial DNA Integrity Is Essential For Mitochondrial Maturation During Differentiation of Neural Stem Cells

21 January 2018

1 reference

The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells

21 January 2018

1 reference

A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans

21 January 2018

1 reference

The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis

21 January 2018

1 reference

A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage

21 January 2018

1 reference

DNA damage in mammalian neural stem cells leads to astrocytic differentiation mediated by BMP2 signaling through JAK-STAT

21 January 2018

1 reference

Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer

21 January 2018

1 reference

Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.

21 January 2018

1 reference

Notch in mammary gland development and breast cancer

21 January 2018

1 reference

Cellular senescence: when bad things happen to good cells

21 January 2018

1 reference

An oncogene-induced DNA damage model for cancer development

21 January 2018

1 reference

Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development

21 January 2018

1 reference

Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

21 January 2018

1 reference

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

21 January 2018

1 reference

Protein complex expression by using multigene baculoviral vectors

21 January 2018

1 reference

Site-specific DICER and DROSHA RNA products control the DNA-damage response

21 January 2018

1 reference

Isolation and characterization of Xenopus ATM (X-ATM): expression, localization, and complex formation during oogenesis and early development

21 January 2018

1 reference

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

21 January 2018

1 reference

Significance analysis of microarrays applied to the ionizing radiation response

21 January 2018

1 reference

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

21 January 2018

1 reference

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

21 January 2018

1 reference

Adjusting batch effects in microarray expression data using empirical Bayes methods

21 January 2018

1 reference

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

21 January 2018

1 reference

Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways

21 January 2018

1 reference

Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression

31 March 2020

1 reference

Activated Notch1 interacts with p53 to inhibit its phosphorylation and transactivation.

31 March 2020

1 reference

Studying DNA Replication Fork Stability in Xenopus Egg Extract

31 March 2020

1 reference

The genetics of Caenorhabditis elegans

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25895060

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25895060

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Notch promotes radioresistance of glioma stem cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25895060

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.3013

1 reference

7 September 2017

1 reference