The Preclinical and Clinical Progress of Bacteriophages and Their Lytic Enzymes: The Parts are Easier than the Whole (Q64251258)

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The Preclinical and Clinical Progress of Bacteriophages and Their Lytic Enzymes: The Parts are Easier than the Whole (English)

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Hans Gerstmans

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Tarek Dishisha

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Yves Briers

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Amal Saafan

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24 January 2019

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Creative Commons Attribution

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Lysozymes from bacteriophages T3 and T5

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12 December 2020

Bacteriophage T7 Lysozyme Is an N-Acetylmuramyl-l-alanine Amidase

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12 December 2020

Purification of bacteriophage T4 lysozyme

1 reference

12 December 2020

The lysozyme of bacteriophage lambda. I. Purification and molecular weight.

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12 December 2020

Structural and genetic analysis of the folding and function of T4 lysozyme

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12 December 2020

Long-circulating bacteriophage as antibacterial agents

1 reference

12 December 2020

Complete nucleotide sequence, molecular analysis and genome structure of bacteriophage A118 of Listeria monocytogenes: implications for phage evolution

1 reference

12 December 2020

Phage therapy: the peculiar kinetics of self-replicating pharmaceuticals

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12 December 2020

Bacteriophage therapy

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12 December 2020

Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme

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12 December 2020

Characterization of an enzyme of phage T2 as a lysozyme

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12 December 2020

Antimicrobial drug discovery through bacteriophage genomics.

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12 December 2020

In vivo recombineering of bacteriophage lambda by PCR fragments and single-strand oligonucleotides.

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12 December 2020

Therapy of experimental pseudomonas infections with a nonreplicating genetically modified phage

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12 December 2020

Alteration of tail fiber protein gp38 enables T2 phage to infect Escherichia coli O157:H7.

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12 December 2020

Lysis-deficient bacteriophage therapy decreases endotoxin and inflammatory mediator release and improves survival in a murine peritonitis model

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12 December 2020

Phage therapy: the Escherichia coli experience

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12 December 2020

An amino acid substitution in a capsid protein enhances phage survival in mouse circulatory system more than a 1000-fold.

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12 December 2020

PlyC: a multimeric bacteriophage lysin

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12 December 2020

Dispersing biofilms with engineered enzymatic bacteriophage

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12 December 2020

BRED: a simple and powerful tool for constructing mutant and recombinant bacteriophage genomes

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12 December 2020

Effects of treatment with antimicrobial agents on the human colonic microflora

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12 December 2020

Site-specific recombination of T2 phage using IP008 long tail fiber genes provides a targeted method for expanding host range while retaining lytic activity.

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12 December 2020

Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial.

1 reference

12 December 2020

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa ; a preliminary report of efficacy

1 reference

12 December 2020

Phage therapy pharmacology.

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12 December 2020

Phage Therapy in Clinical Practice: Treatment of Human Infections

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12 December 2020

Bacteriophage resistance mechanisms

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12 December 2020

Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens

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12 December 2020

Rapid multiplex detection and differentiation of Listeria cells by use of fluorescent phage endolysin cell wall binding domains

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12 December 2020

Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma

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12 December 2020

Purification of phage display-modified bacteriophage T4 by affinity chromatography

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12 December 2020

A T3 and T7 recombinant phage acquires efficient adsorption and a broader host range

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12 December 2020

Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells

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12 December 2020

Bacteriophage endolysins as novel antimicrobials

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12 December 2020

Novel bacteriophage lysin with broad lytic activity protects against mixed infection by Streptococcus pyogenes and methicillin-resistant Staphylococcus aureus

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12 December 2020

Phage lysis: do we have the hole story yet?

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12 December 2020

World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects

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12 December 2020

Art-175 is a highly efficient antibacterial against multidrug-resistant strains and persisters of Pseudomonas aeruginosa

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12 December 2020

Inhibition of biofilm formation by T7 bacteriophages producing quorum-quenching enzymes.

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12 December 2020

Engineered endolysin-based "Artilysins" to combat multidrug-resistant gram-negative pathogens

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12 December 2020

Isolation of a bacteriophage and its depolymerase specific for K1 capsule of Klebsiella pneumoniae: implication in typing and treatment

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12 December 2020

Functional elucidation of antibacterial phage ORFans targeting Pseudomonas aeruginosa

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12 December 2020

Depolymerase improves gentamicin efficacy during Klebsiella pneumoniae induced murine infection

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12 December 2020

Systematic identification of hypothetical bacteriophage proteins targeting key protein complexes of Pseudomonas aeruginosa.

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12 December 2020

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases.

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12 December 2020

Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

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12 December 2020

Breaking barriers: expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria

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12 December 2020

Pre-adapting parasitic phages to a pathogen leads to increased pathogen clearance and lowered resistance evolution with Pseudomonas aeruginosa cystic fibrosis bacterial isolates

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12 December 2020

Complete genome sequence of novel T7-like virus vB_KpnP_KpV289 with lytic activity against Klebsiella pneumoniae.

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12 December 2020

Antibacterial phage ORFans of Pseudomonas aeruginosa phage LUZ24 reveal a novel MvaT inhibiting protein.

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12 December 2020

A bacteriophage journey at the European Medicines Agency

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12 December 2020

Alternatives to antibiotics—a pipeline portfolio review

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12 December 2020

Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh

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12 December 2020

Pharmacokinetics of the phage endolysin-based candidate drug SAL200 in monkeys and its appropriate intravenous dosing period.

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12 December 2020

Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome

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12 December 2020

'Artilysation' of endolysin λSa2lys strongly improves its enzymatic and antibacterial activity against streptococci.

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12 December 2020

Explanation of the Nagoya Protocol on Access and Benefit Sharing and its implication for microbiology

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12 December 2020

Recent advances in (therapeutic protein) drug development.

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12 December 2020

The Lysis of Pathogenic Escherichia coli by Bacteriophages Releases Less Endotoxin Than by β-Lactams

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12 December 2020

Bacteriophage-encoded virion-associated enzymes to overcome the carbohydrate barriers during the infection process

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12 December 2020

Pharmacokinetics and Tolerance of the Phage Endolysin-Based Candidate Drug SAL200 after a Single Intravenous Administration among Healthy Volunteers.

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12 December 2020

φBO1E, a newly discovered lytic bacteriophage targeting carbapenemase-producing Klebsiella pneumoniae of the pandemic Clonal Group 258 clade II lineage

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12 December 2020

Successful Treatment of Chronic Staphylococcus aureus-Related Dermatoses with the Topical Endolysin Staphefekt SA.100: A Report of 3 Cases

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12 December 2020

Pseudomonas predators: understanding and exploiting phage-host interactions.

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12 December 2020

Targeted anti-staphylococcal therapy with endolysins in atopic dermatitis and the effect on steroid use, disease severity and the microbiome: study protocol for a randomized controlled trial (MAAS trial)

1 reference

12 December 2020

Bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomized, placebo-controlled, double-blind clinical trial.

1 reference

12 December 2020

Comparative genome analysis of novel Podoviruses lytic for hypermucoviscous Klebsiella pneumoniae of K1, K2, and K57 capsular types

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12 December 2020

Efficacy of novel anti-staphylococcal ectolysin P128 in a rat model of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia

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12 December 2020

Therapeutic Application of Phage Capsule Depolymerases against K1, K5, and K30 Capsulated E. coli in Mice

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12 December 2020

Synthetic biology of modular endolysins

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12 December 2020

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12 December 2020

Phage Therapy: What Have We Learned?

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12 December 2020

Development of Phage Lysins as Novel Therapeutics: A Historical Perspective

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12 December 2020

A functional type II-A CRISPR-Cas system from Listeria enables efficient genome editing of large non-integrating bacteriophage

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12 December 2020

Efficacy of chimeric ectolysin P128 in drug-resistant Staphylococcus aureus bacteraemia in mice

1 reference

12 December 2020

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

1 reference

12 December 2020

An Alternative Cure: The Adoption and Survival of Bacteriophage Therapy in the USSR, 1922-1955

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12 December 2020

Phage-Borne Depolymerases Decrease Resistance to Innate Defense Mechanisms

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12 December 2020

Bacteriophage Therapy: Clinical Trials and Regulatory Hurdles

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12 December 2020

A chemical defence against phage infection

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12 December 2020

Identifiers

DOI

10.3390/V11020096

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30678377%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30678377%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

PubMed publication ID

30678377

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