ATM serine/threonine kinase (Q141591)

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mammalian protein found in Homo sapiens

• serine-protein kinase ATM
• ataxia telangiectasia mutated
• AT mutated
• A-T mutated
• TEL1, telomere maintenance 1, homolog
• ATM

edit

Language	Label	Description	Also known as
English	ATM serine/threonine kinase	mammalian protein found in Homo sapiens	serine-protein kinase ATM ataxia telangiectasia mutated AT mutated A-T mutated TEL1, telomere maintenance 1, homolog ATM

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q13315

part of

Serine/threonine-protein kinase ATM

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13315

Protein kinase-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13315

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13315

Armadillo-type fold

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13315

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PIK-related kinase, FAT family

1 reference

based on heuristic

inferred from protein domain or family

PIK-related kinase family

1 reference

based on heuristic

inferred from protein domain or family

FATC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Telomere-length maintenance and DNA damage repair, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

ATM 00000.png
2,100 × 2,100; 4.18 MB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q13315

encoded by

ATM

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q13315

molecular function

transferase activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

DNA binding

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

nucleotide binding

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

protein kinase activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

DNA-dependent protein kinase activity

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

protein dimerization activity

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

protein N-terminus binding

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

1-phosphatidylinositol-3-kinase activity

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

kinase activity

determination method

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

protein serine/threonine kinase activity

determination method

IDA

TAS

IEA

7 references

retrieved

16 July 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

TAS

retrieved

16 July 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

16 July 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

16 July 2018

stated in

USP10 regulates p53 localization and stability by deubiquitinating p53

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

16 July 2018

stated in

Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

16 July 2018

stated in

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

16 July 2018

stated in

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IDA

protein binding

determination method

IPI

24 references

retrieved

9 May 2019

stated in

ATM activation by ionizing radiation requires BRCA1-associated BAAT1

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

A role for DEAD box 1 at DNA double-strand breaks

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

MDC1 is a mediator of the mammalian DNA damage checkpoint

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

ATM activation by ionizing radiation requires BRCA1-associated BAAT1

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

Interaction between ATM protein and c-Abl in response to DNA damage

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

Tel2 regulates the stability of PI3K-related protein kinases

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

Systematic identification of molecular links between core and candidate genes in breast cancer

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

Notch is a direct negative regulator of the DNA-damage response

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

retrieved

9 May 2019

stated in

ATMIN defines an NBS1-independent pathway of ATM signalling

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IPI

ATP binding

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

protein-containing complex binding

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

protein serine/threonine kinase activity

determination method

IBA

IDA

IEA

TAS

9 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

TAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

9 May 2019

stated in

USP10 regulates p53 localization and stability by deubiquitinating p53

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

9 May 2019

stated in

Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

9 May 2019

stated in

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

9 May 2019

stated in

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IBA

cell component

cytoplasm

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

DNA repair complex

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

The histone demethylase LSD1/KDM1A promotes the DNA damage response

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

spindle

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

nucleoplasm

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

TAS

telomere

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

cytoplasmic vesicle

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

nucleus

determination method

IDA

IEA

3 references

retrieved

16 July 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

16 July 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

16 July 2018

stated in

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IDA

nucleolus

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

nucleus

determination method

IBA

IDA

IEA

4 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IBA

biological process

somitogenesis

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

response to ionizing radiation

determination method

IDA

IEA

4 references

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

9 May 2019

stated in

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

neuron apoptotic process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

reciprocal meiotic recombination

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

TAS

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

TAS

response to hypoxia

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

female gamete generation

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

determination of adult lifespan

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

phosphorylation

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

establishment of protein-containing complex localization to telomere

determination method

IC

1 reference

retrieved

9 May 2019

stated in

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IC

meiotic telomere clustering

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

peptidyl-serine autophosphorylation

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

DNA damage checkpoint signaling

determination method

IEA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IEA

regulation of telomerase activity

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

positive regulation of telomerase catalytic core complex assembly

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

positive regulation of telomere maintenance via telomerase

determination method

ISS

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

positive regulation of neuron death

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

mitotic spindle assembly checkpoint signaling

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

oocyte development

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

lipoprotein catabolic process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

regulation of cell cycle

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

protein phosphorylation

determination method

IDA

IEA

IMP

3 references

retrieved

9 May 2019

stated in

MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

heart development

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

brain development

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

positive regulation of neuron apoptotic process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

negative regulation of telomere capping

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

positive regulation of telomere maintenance via telomere lengthening

determination method

IMP

2 references

retrieved

9 May 2019

stated in

ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

9 May 2019

stated in

MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

peptidyl-serine phosphorylation

determination method

IDA

2 references

retrieved

9 May 2019

stated in

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

9 May 2019

stated in

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

cellular response to gamma radiation

determination method

IDA

2 references

retrieved

9 May 2019

stated in

Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

9 May 2019

stated in

A role for ATR in the DNA damage-induced phosphorylation of p53

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

intrinsic apoptotic signaling pathway in response to DNA damage

determination method

IEA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IEA

V(D)J recombination

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

positive regulation of apoptotic process

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

regulation of cellular response to heat

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

TAS

pre-B cell allelic exclusion

determination method

ISS

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

cell cycle

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

histone mRNA catabolic process

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

cellular response to nitrosative stress

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

positive regulation of DNA damage response, signal transduction by p53 class mediator

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

double-strand break repair via nonhomologous end joining

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

TAS

negative regulation of B cell proliferation

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

signal transduction

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

TAS

establishment of RNA localization to telomere

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

apoptotic process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

DNA replication

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

TAS

DNA double-strand break processing

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

TAS

regulation of signal transduction by p53 class mediator

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

TAS

regulation of autophagy

determination method

IEA

IMP

2 references

retrieved

9 May 2019

stated in

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

phosphatidylinositol-3-phosphate biosynthetic process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

cellular response to X-ray

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

double-strand break repair via homologous recombination

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

regulation of apoptotic process

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

TAS

negative regulation of TORC1 signaling

determination method

IEA

IMP

2 references

retrieved

24 April 2018

stated in

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

24 April 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IEA

ovarian follicle development

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

immune system process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

immunoglobulin production

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

DNA damage induced protein phosphorylation

determination method

IDA

IMP

2 references

retrieved

9 May 2019

stated in

Molecular and Functional Characterization of a Cohort of Spanish Patients with Ataxia-Telangiectasia

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

9 May 2019

stated in

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

male meiotic nuclear division

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

female meiotic nuclear division

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

female gonad development

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

post-embryonic development

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

multicellular organism growth

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

protein autophosphorylation

determination method

IDA

IMP

3 references

retrieved

9 May 2019

stated in

Molecular and Functional Characterization of a Cohort of Spanish Patients with Ataxia-Telangiectasia

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

9 May 2019

stated in

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

9 May 2019

stated in

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

thymus development

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

chromosome organization involved in meiotic cell cycle

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

DNA repair

determination method

IBA

IEA

2 references

retrieved

16 July 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

16 July 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IBA

cellular response to DNA damage stimulus

determination method

IDA

IEA

IMP

6 references

retrieved

16 July 2018

stated in

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

16 July 2018

stated in

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

16 July 2018

stated in

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

16 July 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

16 July 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

16 July 2018

stated in

Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IDA

regulation of telomere maintenance via telomerase

determination method

IGI

1 reference

retrieved

9 May 2019

stated in

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IGI

positive regulation of DNA catabolic process

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

regulation of microglial cell activation

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

regulation of cellular response to gamma radiation

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

positive regulation of response to DNA damage stimulus

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

telomere maintenance

determination method

IEA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IEA

replicative senescence

determination method

IEA

IMP

2 references

retrieved

1 January 2018

stated in

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

1 January 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

pre-B cell allelic exclusion

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

ISS

protein phosphorylation

determination method

IDA

IMP

2 references

retrieved

1 January 2018

stated in

MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

1 January 2018

stated in

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

regulation of autophagy

determination method

IMP

1 reference

retrieved

1 January 2018

stated in

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

positive regulation of telomere maintenance via telomerase

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

ISS

negative regulation of TORC1 signaling

determination method

IMP

1 reference

retrieved

16 July 2018

stated in

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315

determination method

IMP

DNA damage checkpoint signaling

determination method

IBA

IEA

3 references

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IBA

telomere maintenance

determination method

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IBA

DNA repair

determination method

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

cellular response to DNA damage stimulus

determination method

IBA

IDA

IEA

IMP

7 references

retrieved

9 May 2019

stated in

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

9 May 2019

stated in

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

9 May 2019

stated in

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q13315

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IBA

intrinsic apoptotic signaling pathway in response to DNA damage

determination method

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IBA

positive regulation of gene expression

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

positive regulation of cell migration

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

positive regulation of cell adhesion

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

ISS

positive regulation of transcription by RNA polymerase II

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

ISS

cellular response to retinoic acid

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

ISS

negative regulation of TORC1 signaling

determination method

IBA

IMP

2 references

retrieved

1 January 2018

stated in

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IBA

intrinsic apoptotic signaling pathway in response to DNA damage

determination method

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IBA

positive regulation of cell adhesion

determination method

IEA

ISS

2 references

retrieved

9 May 2019

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

positive regulation of transcription by RNA polymerase II

determination method

IEA

ISS

2 references

retrieved

9 May 2019

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

cellular response to retinoic acid

determination method

IEA

ISS

2 references

retrieved

9 May 2019

stated in

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

replicative senescence

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

negative regulation of TORC1 signaling

determination method

IBA

IEA

IMP

3 references

retrieved

9 May 2019

stated in

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IMP

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315

determination method

IBA

exact match

http://purl.uniprot.org/uniprot/Q13315

1 reference

stated in

Identifiers.org

has part(s)

PIK-related kinase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13315

Telomere-length maintenance and DNA damage repair

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13315

FATC domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13315

PIK-related kinase, FAT

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13315

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13315

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q13315

Identifiers

RefSeq protein ID

NP_000042

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

XP_005271619

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

XP_006718906

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

XP_006718908

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

XP_011541142

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

XP_011541144

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

XP_011541145

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

XP_011541146

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

XP_011541147

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

XP_016873278

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

XP_016873279

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

XP_016873280

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

XP_016873281

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

NP_001338763

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

NP_001338764

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

NP_001338765

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

472

UniProt protein ID

Q13315

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q13315

Ensembl protein ID

ENSP00000278616

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000278616

ENSP00000388058

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000388058

ENSP00000432318

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000432318

ENSP00000433955

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000433955

ENSP00000434327

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000434327

ENSP00000435524

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000435524

ENSP00000435747

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000435747

ENSP00000469471

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000469471

ENSP00000480205

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000480205

ENSP00000483338

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000483338

ENSP00000491585

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000491585

ENSP00000491957

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000491957

ENSP00000492354

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000492354

ENSP00000492487

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000492487

Freebase ID

/m/06v1r8

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

 

Sitelinks

Wikipedia(13 entries)

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• bswiki Mutirana ataksija telangiektazija
• dewiki ATM-Kinase
• enwiki ATM serine/threonine kinase
• eswiki ATM (gen)
• frwiki Protéine ATM
• glwiki Proteína ATM
• huwiki ATM szerin/treonin-kináz
• itwiki Serina/treonina protein-chinasi ATM
• jawiki ATM (タンパク質)
• plwiki Kinaza ATM
• ruwiki ATM (белок)
• ttwiki ATM (ген)
• ukwiki ATM (ген)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q141591&oldid=2155283623"