The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint
Abstract
:1. Introduction
2. Current Knowledge on MicroRNAs Involved in PD-1/PD-L1 Regulation
2.1. MicroRNAs That Regulate PD-1/PD-L1 Directly
2.1.1. MicroRNAs Regulating PD-1 Expression
2.1.2. MicroRNAs Regulating PD-L1 Expression
2.2. Potential PD-1/PD-L1 Regulatory microRNAs
2.2.1. MicroRNAs Regulating IFN-γ Expression
2.2.2. MicroRNAs Regulating IFNGR Expression
2.2.3. MicroRNAs Regulating STAT1 Expression
2.2.4. MicroRNAs Regulating IRF1 Expression
2.2.5. MicroRNAs Regulating PTEN Expression
2.2.6. MicroRNAs Regulatingm TOR Expression
2.2.7. MicroRNAs Regulating Eukaryotic Translation Initiation Factor 4B (EIF4B) Expression
2.2.8. MicroRNAs Regulating SHP2 Expression
2.2.9. MicroRNAs Regulating c-Fos Protein (c-Fos) Expression
3. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Target mRNA | miRNA | Host | Reference |
---|---|---|---|
PD-1 | miR-28 | melanoma | Li et al. [17] |
miR-138 | glioblastoma | Wei et al. [18] | |
miR-4717 | HCC | Zhang et al. [19] | |
PD-L1 | miR-15a | MPM | Kao et al. [20] |
miR-15b | MPM | Kao et al. [20] | |
miR-16 | MPM | Kao et al. [20] | |
miR-34a | AML | Wang et al. [21] | |
miR-93 | MSC | Cioffi et al. [22] | |
miR-106b | MSC | Cioffi et al. [22] | |
miR-138-5p | CRC | Zhao et al. [23] | |
miR-142-5p | PC | Jia et al. [24] | |
miR-152 | GC | Wang et al. [25] | |
miR-193a-3p | MPM | Kao et al. [20] | |
miR-200 | GC | Chen et al. [26] | |
miR-324-5p | Treg | Holla et al. [27] | |
miR-338-5p | Treg | Holla et al. [27] | |
miR-424 | OC | Xu et al. [28] | |
miR-513 | Cholangiocytes | Gong et al. [29] | |
IFN-γ | miR-181a | aGVHD | Sang et al. [30] |
miR-24-2 | HeLa | Wang et al. [31] | |
miR-200c | HeLa | Wang et al. [31] | |
IFNGR | miR-378 | CL | Ma et al. [32] |
STAT1 | miR-27a | HeLa | Wang et al. [31] |
miR-145 | CC | Gregersen et al. [33] | |
miR-146a | Treg | Lu et al. [34] | |
miR-150 | ATL | Moles et al. [35] | |
miR-223 | ATL | Moles et al. [35] | |
miR-200c | HeLa | Wang et al. [31] | |
IRF1 | miR-23b | DF-1 | Li et al. [36] |
miR-383 | TEC | Lian et al. [37] | |
PTEN | miR-10a | NSCLC | Yu et al. [38] |
miR-19a | GC | Wang et al. [39] | |
miR-19b | GC | Wang et al. [39] | |
miR-20b | CRC | Zhu et al. [40] | |
miR-21 | CRC | Zhu et al. [40] | |
miR-26a | LC | Liu et al. [41] | |
miR-92a | CRC | Zhang et al. [42] | |
miR-106b | GC | Yang et al. [43] | |
miR-205 | NPC | Qu et al. [44] | |
miR-214 | OC | Yang et al. [45] | |
miR-221 | GC | Zhang et al. [46] | |
miR-222 | GC | Zhang et al. [46] | |
miR-301a | BC | Ma et al. [47] | |
miR-494 | MDSCs | Liu et al. [48] | |
MTOR | miR-100 | BLC | Xu et al. [49] |
miR-101 | OTC | Lin et al. [50] | |
miR-199a-3p | EEC | Wu et al. [51] | |
miR-497 | OC | Xu et al. [52] | |
EIF4B | miR-150 | HSC | Fang et al. [53] |
miR-216a | NSCLC | Wang et al. [54] | |
SHP2 | miR-204 | PASMCs | Courboulin et al. [55] |
FOS | miR-101 | OS | Wang et al. [56] |
miR-139-5p | PBC | Katsumi1 et al. [57] | |
miR-155 | DCs | Dunand-Sauthier et al. [58] | |
miR-181a | DCs | Wu et al. [59] | |
miR-181b | MG | Tao et al. [60] | |
miR-490-5p | BLC | Li et al. [61] |
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Share and Cite
Wang, Q.; Lin, W.; Tang, X.; Li, S.; Guo, L.; Lin, Y.; Kwok, H.F. The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint. Int. J. Mol. Sci. 2017, 18, 2540. https://doi.org/10.3390/ijms18122540
Wang Q, Lin W, Tang X, Li S, Guo L, Lin Y, Kwok HF. The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint. International Journal of Molecular Sciences. 2017; 18(12):2540. https://doi.org/10.3390/ijms18122540
Chicago/Turabian StyleWang, Qingshui, Wei Lin, Xiaoqiong Tang, Suhuan Li, Libin Guo, Yao Lin, and Hang Fai Kwok. 2017. "The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint" International Journal of Molecular Sciences 18, no. 12: 2540. https://doi.org/10.3390/ijms18122540