Signaling and Gene Regulation in Metabolism
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (25 October 2023) | Viewed by 11902
Special Issue Editors
Interests: signal transduction; cancer; insulin; metabolism; T lymphocytes
Special Issues, Collections and Topics in MDPI journals
Interests: nutritional microenvironment in tumor development and drug response; metabolism and epigenetics; protein phosphatase regulation in diabetes and obesity
Special Issue Information
Dear Colleagues,
Nutrient metabolism generates fuel and biosynthetic precursors necessary for cellular and organismal growth. The consumption and metabolism of nutrients are controlled by signaling pathways that respond to fluctuations in nutrient levels. These signaling pathways also integrate other environmental inputs including the presence of growth signals and stress stimuli. The transduction of signals from the cellular membrane to the nucleus leads to regulation of gene expression, which ultimately allows cells to establish metabolic homeostasis, which is necessary to prevent disease. Understanding how signaling and changes in gene expression reprogram metabolism and how defects in these processes lead to pathological conditions will facilitate the development of better therapeutic strategies against metabolism-related disorders. The mTOR and AMPK signaling pathways control a variety of metabolic effectors but the role of other signaling molecules also deserve further investigation. This Special Issue aims to gather new insights on how different signaling pathways control various metabolic processes. Other topics of relevance to this Special Issue also include: how various types of nutrients or metabolites are sensed, modulation of nutrient uptake and metabolism, coordinated regulation of metabolic processes, and transcriptional and epigenetic control of metabolic processes. We will also highlight underlying mechanisms, therapeutic strategies and dietary manipulations involving metabolic-related disorders.
Prof. Dr. Estela Jacinto
Prof. Dr. Mei Kong
Guest Editors
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Keywords
- metabolism
- signaling to metabolism
- regulation of metabolic pathways
- nutrients
- dietary manipulations in cancer and other metabolic disorders
- mTOR/AMPK pathways
- insulin/PI3K signaling
- cell growth and proliferation
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