PYRAZINAMIDE
IISc researchers design novel 3D hydrogel culture to study TB infection and treatment
Mycobacterium tuberculosis (Mtb) is a dangerous pathogen. In 2022, it affected 10.6 million people and caused 1.3 million deaths, according to the WHO. “It is a very old bug, and it has evolved with us quite a bit,” said Rachit Agarwal, Associate Professor at BE. Mtb primarily infects the lungs, IISc said in a press release.
No shortage of anti-TB drugs in India, asserts Health Ministry
The treatment regimen of multi drug resistant TB consists of usually four months of seven drugs (bedaquiline, levofloxacin, clofazimine, isoniazid, ethambutol, pyrazinamide and ethionamide) followed by five months of 4 drugs (levofloxacin, clofazimine, pyrazinamide and ethambutol). In about 30 pc of persons with drug resistant TB, cycloserine and linezolid is required.
Mumbai pharma company gets licence for breakthrough TB drug
A global non-profit drug developer TB Alliance has tied up with domestic company Macleods Pharmaceuticals to develop and commercialise its ‘breakthrough’ drug Pretomanid in high-burden countries, including India.
States must invest in R&D to fund new drug discoveries: TB Alliance
Generic manufacturers are essential players in the fight to end TB so we do speak with generic manufacturers as part of our access strategy.
Semler gets WHO notice of concern over violation of ideal laboratory and clinical practices
The WHO said its findings bring into question the validity of studies (performed for 12 products) that are under assessment, but not prequalified.
Move to ban fixed-dose combinations a culmination of efforts to free market from irrational drugs
The US Food & Drug Administration has favoured use of FDCs for HIV treatments, but approval process is rigorous.
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Anuh Pharma recovers 14% from day's low on suspended drugs clarification
“The company does not expect significant effect on its top & bottom line since the company have very good presence in Indian and rest of world’s market,” the company told BSE.
European drug regulator suspends Anuh Pharma's three drugs
Following the inspection of it's manufacturing site, European Directorate for the Quality of Medicines and Healthcare has suspended certificates of Anuh Pharma.
TB treatment could be shortened, show trials
The effectiveness of the four-month regimen was proved on the basis of recurrence levels, number of patients testing negative in sputum smears and adverse effects to the drugs.
Drug combo speeds up TB treatment
The drug combination, known as PaMZ, killed more bacteria than standard treatment and was effective in treating drug-resistant tuberculosis.
World TB day: Need to raise public spend on clinical trials & find innovative ways to incentivise R&D
March 24 is World TB day. It commemorates the discovery of Tuberculosis (TB) bacillus in 1883 by Dr Robert Koch as the cause of tuberculosis.
Lupin signs strategic deal with Brazilian firm Farmanguinhos
Pharma Major, Lupin Ltd today announced that it has entered into an agreement with Farmanguinhos for the supply of its 4 in 1 combination drug of Rifampicin, Isoniazide, Ethambutol and Pyrazinamide for tuberculosis.
Lupin inks pact with Brazil for TB drug supply for 5 yrs
Drug firm Lupin today said it has signed an agreement with Brazil to supply its four-in-one combination drug to treat tuberculosis.
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