The Technology Development Coordinating Center is responsible for enhancing integration between components of the NHGRI Genome Technology program by facilitating opportunities for collaborations and leading efforts to promote standards in genomic technologies. The Coordinating Center also disseminates program advances, develops resources and outreach strategies for engaging the broader biomedical research community, and manages an Opportunity Funds program to rapidly fund and support promising small-scale work that advances development of innovative genomic technologies.
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This newly released pub notes the enhanced ability of uMRT to detect a broader range of isoforms, which is a crucial factor in #RNAseq.
"uMRT's read length advantage resulted in a 22% increase in isoform detection compared to Maxima, offering greater depth and accuracy in uncovering transcript diversity."
Read the full publication: https://bit.ly/3X09Swh#RNA
Understanding the function of an entire genome is no easy task! Most genes likely have more than one function and behave differently depending on context.
To understand the functional effects of genomic variation, NHGRI launched a consortium called Impact of Genomic Variation on Function (IGVF). This consortium now involves researchers from over 120 laboratories across the country who are using multiple experimental and computational techniques to determine the effects of genomic variation. Learn more about this important program! https://lnkd.in/d7--uVXn
📽 Publication Highlight Video https://lnkd.in/eXJzuHpUDerek Stein and Nicholas Drachman of Brown University, discuss their innovative development in mass spectrometry-based proteomics, published in Nature Communications. They developed nanopore ion sources to deliver single ions of individual amino acids and peptides directly into high vacuum from biologically relevant aqueous solutions. This work makes significant improvements over conventional electrospray ionization methods. This is a huge step forward for mass spectrometry—a technique used to measure the mass of molecules—and its significance in proteomics, where understanding protein structure and function is critical for advancing biology and medicine.
Read the full paper in Nature Communications:
https://lnkd.in/ezknfX8K#massspectrometry#nanopore#proteomics
In this keynote address by Stacey Gabriel of Broad Institute of MIT and Harvard given at the Genome Technology Forum, a hybrid event hosted by the Genome Technology Development Coordinating Center at The Jackson Laboratory in collaboration with National Human Genome Research Institute (NHGRI), Dr. Gabriel focuses on human genomics, particularly in the areas of large-scale genomic studies. Her talk encompasses several key areas:
1. Human Genome Sequencing at Scale
2. Pathways to Clinical Integration of Genome Sequencing
3. Reducing Sequencing Costs with Blended Genome-Exome Sequencing
4. Utilization of Ultima Genomics UG100 Sequencer
5. Advancing Gene Function Analysis Beyond Genomes
Dr. Gabriel’s presentation underscores the transformative potential of large-scale genome sequencing and its integration into clinical practice. By leveraging advanced technologies and innovative approaches, her work at the Broad Institute of MIT and Harvard is paving the way for precision medicine, where genomic information drives personalized healthcare strategies. Additionally, her forward-looking perspective on gene function analysis promises to further unravel the complexities of the human genome, leading to new discoveries and therapeutic opportunities.
https://lnkd.in/expZkwhx
What is #CRISPR and how does it work?
✂️🧬 Gain an understanding of utilizing CRISPR/Cas9 gene editing technology through The Jackson Laboratory's free Basics of CRISPR/Cas9 online course: https://lnkd.in/eEiAvN2f
Topics to be covered:
🔹 Basic mechanism of CRISPR/Cas9 genome engineering technology
🔹 Somatic cell and germline gene editing
🔹 CRISPR/Cas9 strategies to create a better mouse model
🔹 CRISPR/Cas9 complications, including off-target events and founder mosaicism
🔹 Practical applications in the clinic
I'm hiring! Join our team and contribute to the development of complete, personalized “telomere-to-telomere” (T2T) genome assemblies and the analysis of previously inaccessible regions of the genome! We are currently accepting applications for center coordinator, bioinformatics engineer/scientist, and postdoctoral researcher. More info: https://lnkd.in/eAZAVHAk
They are not an unlikely duo, but rather a perfect, complementary pair! DNA and RNA are very similar, but they have unique biological roles. RNA and DNA are both a type of molecule called a nucleic acid, but their structures are different in subtle ways.
DNA stores genetic information to help your body develop and function. Towards that same goal, your cells use RNA for a number of tasks, including copying that genetic information to make important proteins for your body.
Learn more about the differences between these two in our fact sheet! https://lnkd.in/eS-8AKPh
Jef Boeke, NYU Langone Health, discusses groundbreaking advancements in genetic engineering and synthetic biology, highlighting the innovative "Assemblatron," and the ambitious "Dark Matter Project."
https://lnkd.in/erJfmDVN
Boeke begins by explaining the concept of synthetic genomes and "Big DNA" and showcasing how scientists can design and construct DNA from scratch to create entirely new organisms or modify existing ones.
Boeke introduces the "Assemblatron," a cutting-edge platform designed to automate the assembly of large DNA constructs. He discusses how this technology can accelerate research and development in synthetic biology, making it possible to create complex genetic systems more efficiently and accurately.
The presentation then transitions to the "Dark Matter Project," an initiative aimed at uncovering the unknown functions of vast regions of non-coding DNA, often referred to as the "dark matter" of the genome. Boeke shares insights into how this project could revolutionize our understanding of genetics and lead to novel discoveries and gene therapies. Boeke describes the development of an animal model for X-Linked dystonia-parkinsonism (XDP) and how a synthetic genomics approach to investigate the XDP/TAF1 locus has potential to lead to the development of gene therapies.
Whether you're a scientist, student, or simply curious about the future of genetics, this presentation offers a captivating glimpse into the possibilities of synthetic genomes and the innovative projects driving the field forward.
This presentation was part of the Genome Technology Forum, a hybrid event held at The Jackson Laboratory in collaboration with the National Human Genome Research Institute (NHGRI).