Genome Technology Development Coordinating Center

In this keynote address by Stacey Gabriel of Broad Institute of MIT and Harvard given at the Genome Technology Forum, a hybrid event hosted by the Genome Technology Development Coordinating Center at The Jackson Laboratory in collaboration with National Human Genome Research Institute (NHGRI), Dr. Gabriel focuses on human genomics, particularly in the areas of large-scale genomic studies. Her talk encompasses several key areas: 1. Human Genome Sequencing at Scale 2. Pathways to Clinical Integration of Genome Sequencing 3. Reducing Sequencing Costs with Blended Genome-Exome Sequencing 4. Utilization of Ultima Genomics UG100 Sequencer 5. Advancing Gene Function Analysis Beyond Genomes Dr. Gabriel’s presentation underscores the transformative potential of large-scale genome sequencing and its integration into clinical practice. By leveraging advanced technologies and innovative approaches, her work at the Broad Institute of MIT and Harvard is paving the way for precision medicine, where genomic information drives personalized healthcare strategies. Additionally, her forward-looking perspective on gene function analysis promises to further unravel the complexities of the human genome, leading to new discoveries and therapeutic opportunities. https://lnkd.in/expZkwhx

What is #CRISPR and how does it work? ✂️🧬 Gain an understanding of utilizing CRISPR/Cas9 gene editing technology through The Jackson Laboratory's free Basics of CRISPR/Cas9 online course: https://lnkd.in/eEiAvN2f Topics to be covered: 🔹 Basic mechanism of CRISPR/Cas9 genome engineering technology 🔹 Somatic cell and germline gene editing 🔹 CRISPR/Cas9 strategies to create a better mouse model 🔹 CRISPR/Cas9 complications, including off-target events and founder mosaicism 🔹 Practical applications in the clinic

Why work with DNA that only has 4 nucleotides when you can use 6 or more? Steve Benner of FfAME - Foundation for Applied Molecular Evolution and Firebird Biomolecular Sciences LLC provides a stimulating presentation on synthetic biology and the application of Artificially Expanded Genetic Information Systems (AEGIS). https://lnkd.in/e3Eeq3Kw

I'm hiring! Join our team and contribute to the development of complete, personalized “telomere-to-telomere” (T2T) genome assemblies and the analysis of previously inaccessible regions of the genome! We are currently accepting applications for center coordinator, bioinformatics engineer/scientist, and postdoctoral researcher. More info: https://lnkd.in/eAZAVHAk

They are not an unlikely duo, but rather a perfect, complementary pair! DNA and RNA are very similar, but they have unique biological roles. RNA and DNA are both a type of molecule called a nucleic acid, but their structures are different in subtle ways.    DNA stores genetic information to help your body develop and function. Towards that same goal, your cells use RNA for a number of tasks, including copying that genetic information to make important proteins for your body.    Learn more about the differences between these two in our fact sheet! https://lnkd.in/eS-8AKPh

Jef Boeke, NYU Langone Health, discusses groundbreaking advancements in genetic engineering and synthetic biology, highlighting the innovative "Assemblatron," and the ambitious "Dark Matter Project." https://lnkd.in/erJfmDVN Boeke begins by explaining the concept of synthetic genomes and "Big DNA" and showcasing how scientists can design and construct DNA from scratch to create entirely new organisms or modify existing ones. Boeke introduces the "Assemblatron," a cutting-edge platform designed to automate the assembly of large DNA constructs. He discusses how this technology can accelerate research and development in synthetic biology, making it possible to create complex genetic systems more efficiently and accurately. The presentation then transitions to the "Dark Matter Project," an initiative aimed at uncovering the unknown functions of vast regions of non-coding DNA, often referred to as the "dark matter" of the genome. Boeke shares insights into how this project could revolutionize our understanding of genetics and lead to novel discoveries and gene therapies. Boeke describes the development of an animal model for X-Linked dystonia-parkinsonism (XDP) and how a synthetic genomics approach to investigate the XDP/TAF1 locus has potential to lead to the development of gene therapies. Whether you're a scientist, student, or simply curious about the future of genetics, this presentation offers a captivating glimpse into the possibilities of synthetic genomes and the innovative projects driving the field forward. This presentation was part of the Genome Technology Forum, a hybrid event held at The Jackson Laboratory in collaboration with the National Human Genome Research Institute (NHGRI).

RNA Day is AUGust 1st! 🎉 Did you know that RNA molecules undergo chemical modifications comprising the epitranscriptome? Tao Pan of University of Chicago provides an overview of RNA mods, how they are detected, and how they can be used in therapeutics. https://lnkd.in/gh5UnB-P This presentation was part of the Genome Technology Forum, a hybrid event hosted at The Jackson Laboratory in collaboration with National Human Genome Research Institute (NHGRI)

To have genomics research that’s gold-medal worthy, we need to look beyond having one human genome sequence! One sequence can’t possibly represent everyone’s genomic diversity.   That’s why researchers are working on a pangenome, a collection of complete genome sequences in which human populations and their genomic variants are better represented!   Researchers from the international Human Pangenome Reference Consortium have released a high-quality collection of complete reference human genome sequences! This will help make genomics studies more diverse and representative of all people! https://lnkd.in/eBNF7SXJ

Dive into the key steps of extracting human DNA from a saliva sample in this virtual lab, created by The Jackson Laboratory on LabXchange. In this virtual lab, you will go through the process of: ✔️ Collecting samples ✔️ Separating DNA from other components ✔️ Cleaning the DNA Step into the shoes of a scientist without leaving your classroom: https://ow.ly/3ufZ50SJQhr #VirtualLab #DNAExtraction #ScienceEducation #SciEd #STEM #JacksonLabs #Genetics #MolecularBiology #ExperimentalDesign #ScientificMethod

Alejandro Chavez and Joonwon Kim of UC San Diego discuss their recent 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗔𝗱𝘃𝗮𝗻𝗰𝗲𝘀 publication on high-throughput insertion of tags across the genome (HITAG). This cutting-edge technique enables rapid and efficient tagging of endogenous proteins, providing an invaluable tool for the large-scale interrogation of protein function. https://lnkd.in/eg8p4ijG 𝗪𝗵𝗮𝘁 𝗶𝘀 𝗛𝗜𝗧𝗔𝗚? HITAG (High-Throughput Insertion of Tags Across the Genome) is a novel method designed to facilitate the study of protein function on a large scale. By leveraging a modified Cas9-based targeted insertion strategy that relies on nonhomologous end joining (NHEJ), HITAG allows for the rapid creation of libraries of cells, each containing a different protein of interest tagged at the C-terminus. 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀: Using HITAG, the researchers fused mCherry to a set of 167 stress granule-associated proteins. This enabled them to elucidate the features driving a subset of proteins to accumulate strongly within these transient RNA-protein granules. 𝗪𝗵𝘆 𝗶𝘀 𝗛𝗜𝗧𝗔𝗚 𝗜𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝘁? Understanding the dynamic behavior and interaction partners of proteins is crucial for building an accurate working model of the cell. Protein tags, such as those created by HITAG, facilitate numerous studies, including in vivo protein localization, affinity purification, and rapid protein degradation. 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗳𝘂𝗹𝗹 𝗮𝗿𝘁𝗶𝗰𝗹𝗲 𝗶𝗻 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗔𝗱𝘃𝗮𝗻𝗰𝗲𝘀: https://lnkd.in/eWgWv4q9 𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗰𝗼𝗻𝘀𝘁𝗿𝘂𝗰𝘁𝘀 𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗹𝗲 𝗮𝘁 𝘁𝗵𝗲 𝗻𝗼𝗻𝗽𝗿𝗼𝗳𝗶𝘁 𝗿𝗲𝗽𝗼𝘀𝗶𝘁𝗼𝗿𝘆, 𝗔𝗱𝗱𝗴𝗲𝗻𝗲 https://lnkd.in/e4SMybuk 𝗟𝗲𝗮𝗿𝗻 𝗺𝗼𝗿𝗲 𝗮𝗯𝗼𝘂𝘁 𝘁𝗵𝗲 𝗖𝗵𝗮𝘃𝗲𝘇 𝗟𝗮𝗯 𝗮𝗻𝗱 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗶𝗻𝘁𝗲𝗿𝗲𝘀𝘁𝘀: https://chavezlab.com/ Discover more about the 𝗡𝗛𝗚𝗥𝗜 𝗢𝗽𝗽𝗼𝗿𝘁𝘂𝗻𝗶𝘁𝘆 𝗙𝘂𝗻𝗱𝘀 and the research supported through the NHGRI Genome Technology Program: https://lnkd.in/eMJUeNg3